Molecular and biochemical studies of Alzheimer's disease have recently under gone a major revolution with the discovery of the presenilin genes. Since 1995 when these genes were first identified to carry defects responsible for up to half of early onset familial Alzheimer's disease cases (Sherrington et al. 1995; Levy-Lahad et al. 1995), over 50 Alzheimer-associated mutations have been found in the prese nilin genes, PSI and PS2 (reviewed in Tanzi et al. 1996). Over 200 papers have been published regarding the characterization of the presenilins. Not since the amyloid protein Precursor (APP)...
Molecular and biochemical studies of Alzheimer's disease have recently under gone a major revolution with the discovery of the presenilin genes. Since...
