The controlled clinical trial has become an essential part of the clinician's decision-making process. Clinical trials, however, still raise methodological problems that are important and at the same time controversial: subgroup analysis and interactions, meta-analy- sis of similar trials, consideration of subjective clinical opinions and those of the public at large, assessment of quality of life, pre- vention trials, and so on. In February 1987 we took our third step along the road to evaluating these issues in dialogues between cli- nicians, psychologists, legal experts, and statisticians....
The controlled clinical trial has become an essential part of the clinician's decision-making process. Clinical trials, however, still raise methodolo...
