All organisms adapt, or at least try to adapt, to informa- tion or signals arising from their surrounding environment. This can affect the behaviour of the entire organism or the functioning of discrete organs or areas within an organism, depending upon its degree of complexity. This workshop was set up with the aim of encouraging discussions and collaboration between investiga- tors studying a wide spectrum of signal transduction/sensing events occurring at the cell surface in systems where the sig- nalling mechanisms became attenuated or desensitized after their initial...