An integrated approach with Geographic Information Systems (GIS) and Remote Sensing (RS) was adopted to assess the groundwater potential in the southern lowlands of Ethiopia, Moyale-Teltele sub-basin of the Genale Dawa river basin. Six geologic, physiographic, and hydrologic factors were applied namely: lithology, structure, geomorphology, slope, land cover, and drainage. Satty's Analytical Hierarchy Process was utilized in giving ranks and weights to the layers and different classes in them. Weighted Overlay Analysis was implemented in ArcGIS to combine the thematic layers and produce the...