Real-world systems that involve some non-smooth change are often well-modeled by piecewise-smooth systems. However there still remain many gaps in the mathematical theory of such systems. This doctoral thesis presents new results regarding bifurcations of piecewise-smooth, continuous, autonomous systems of ordinary differential equations and maps. Various codimension-two, discontinuity induced bifurcations are unfolded in a rigorous manner. Several of these unfoldings are applied to a mathematical model of the growth of Saccharomyces cerevisiae (a common yeast). The nature of resonance near...