Prostaglandin is a product of cyclooxygenase-2. Compelling epidemiological and experimental studies over the last few decades have suggested that elevated cyclooxygenase-2 activity has been associated with enhanced development and spread of colorectal cancer, although the exact mechanisms of action are largely unknown or poorly understood. Modulation of adhesion molecules allows colorectal cancer cells to break away from their primary site and invade into the extracellular matrix: the initial process of metastasis. Other molecules such as Metalloproteinases, Cluster differentiation 44 and...

Technology is a key driver behind the effects of contemporary globalization on business and other organizations worldwide. Understanding this phenomena in connection with the impact of cultural variations can help improve business and product life cycles in an era in which corporate capital and liquidity buffers must be increased for unexpected developments in global markets. Cultural and Technological Influences on Global Business is a leading publication in its field emphasizing the importance of deeply exploring the effects of cultures and technologies on the global business sector. This...