For some period of time the use of plasma in medicine has been limited to thermal discharges for cauterization and dissection. Non-thermal plasma, on the other hand, can have many different modes of interaction with tissue. It has been recently demonstrated that direct treatment of smooth surfaces by non-thermal dielectric barrier discharge (DBD) in air is highly effective in killing pathogens and DBD can create different sub-lethal and selective effects. However, a typical DBD in air can be highly non-uniform, particularly on topographically non-uniform surfaces such as in most living...