The dystroglycans (DGs), and -DG, form the core of the dystrophin glycoprotein complex in the skeletal muscle as a transmembrane linkage between the cytoskeleton and the extracellular matrix. Disruption of this linkage leads to muscular dystrophy. DG is also implicated in synaptogenesis of the neuromuscular junction. In the central nervous system (CNS), however, roles of DG remain largely unknown. As a step toward revealing the function of DG in the CNS, affinity-purified rabbit antisera against -DG were raised and tested, which recognize only DG in brain extracts. Immunocytochemistry with...