BACE inhibitors and their use in the treatment of Alzheimer's Disease

BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery.

This book details the story...

Going through historical and biographical details, Gertrude Stein American Modernist: Writing Painting and the Feminist Other draws parallels between the concerns and methods of modernist painting, and those that preoccupied Gertrude Stein. Using principles of the semiotics of writing and painting, the book develops a general framework for reading some of the major works of Stein, and examines her importance as a writer. "Just as cubist painting evolved through a series of experiments in the analysis of vision and of its depiction in art, Gertrude Stein's work can be seen to pass through a...