� This book is an ideal guide to umbrella reviews, overviews of reviews, and meta-epidemiologic studies for evidence synthesis. Research is conducted at different levels: primary research consists of original studies while secondary research comprises qualitative reviews, systematic reviews, and meta-analyses.

This book is the first exclusively devoted to the systematic synthesis of diagnostic test accuracy studies. After a section dedicated to methods for designing reviews, synthesizing evidence and appraising inconsistency in research, the application of these methods is demonstrated in the context of case studies from various clinical disciplines.