Herpes simplex virus-1 (HSV-1) and Herpes simplex
virus-2 (HSV-2) are large, enveloped DNA viruses.
They were the first human herpes viruses to be
discovered and are amongst the most intensively
investigated. Prof. Kenneth Rosenthals lab has
demonstrated that differences in virulence and
tissue culture behavior for some HSV-1 strains can
be attributed to variation in the ICP34.5 gene and
protein. ICP34.5 binds to PP1 to dephosphorylate
eIF2alpha and stop HSV induced ER stress and
inhibition of protein synthesis. T-cell like
intracellular antigen-1 (TIA-1) and its closely
related...