An important method for statistical validation is the receiver operating characteristic (ROC) analysis. This visual tool is used in a variety of clinical areas, including laboratory testing, epidemiology, radiology, and bioinformatics, for evaluating diagnostic tests. This book gives a historical overview of the empirical and nonparametric ROC method for continuous diagnostic and classification data. It introduces methods for estimating and comparing ROC curves based on diagnostic test results and covers both semiparametric and parametric models. The authors develop likelihood-based...

Advancing the development, validation, and use of patient-reported outcome (PRO) measures, Patient-Reported Outcomes: Measurement, Implementation and Interpretation helps readers develop and enrich their understanding of PRO methodology, particularly from a quantitative perspective. Designed for biopharmaceutical researchers and others in the health sciences community, it provides an up-to-date volume on conceptual and analytical issues of PRO measures.

The book discusses key concepts relating to the measurement, implementation, and interpretation of PRO...