Stroke is one of the leading causes of disability
and the hemiplegic upper extremity is particularly
resistant to rehabilitation intervention. Endurance
exercise, outside of its beneficial effects on the
cardiovascular and musculoskeletal systems,
influences brain remodelling, learning, and memory.
In our experiments, we determined the effects of
exercise on critical mediators of neuroplasticity
(brain-derived neurotrophic factor (BDNF), insulin-
like growth factor (IGF-I), synapsin-I,
phosphorylated cyclic AMP response element binding
protein (pCREB) and serum corticosterone) in a...