Melanoma is the most aggressive skin tumour and the number of cases and deaths has increased faster than many other cancers. Activating mutations in the B-RAF and N-RAS proto-oncogenes and deletion of the tumour suppressor gene CDKN2A occur at high frequencies in melanomas. This study characterises the widely unknown consequences of the most prominent somatic alterations in the B-RAF, N-RAS, and CDKN2A genes on gene expression in melanoma. Additionally, the effect of the V600E B-RAF mutation on gene expression in benign melanocytic nevi, known precursors of melanoma, was examined. In summary,...