Carcinogenesis is commonly described as a multistage process. In a first step, a stem cell is transformed via a series of mutations into an intermediate cell having a growth advantage. Under favorable conditions, such a cell will give rise to a clone of initiated cells. At some point, further alterations may transform a cell out of this clone into a malignant tumor cell. A mechanistic model of this process is given by the widely used two-stage clonal expansion model. In this text, Sandro Gsteiger studies how to introduce population heterogeneity into this model. Mixture modeling, which allows...