This monograph focuses on the design and study of
innovative polymeric drug delivery systems for
acidic solid cancer tumors. A sulfonamide-based pH-
sensitive polymer was developed to mask conventional
delivery systems such as gene carrier and polymeric
micelles, during systemic circulation and unmask
them at the acidic tumor. First a pH-sensitive
polymer (PSD-b-PEG) was evaluated in a gene delivery
model. Plasmid DNA was complexed with PEI, this
further complexed with PSD-b-PEG to construct a
nanoparticle. The nanoparticles showed low
cytotoxicity (20%) and low transfection at pH...