This book describes the design, physicochemical
characterisation and clinical evaluation of
bioadhesive drug delivery systems for photodynamic
therapy of difficult-to-manage vulval neoplasias and
dysplasias. In photodynamic therapy (PDT), a
combination of visible light and a sensitising drug
causes the destruction of selected cells. ALA is
commonly delivered to the vulva using creams or
solutions, which are covered with an occlusive
dressing to aid retention and enhance drug
absorption. Such dressings are poor at staying in
place at the vulva, where shear forces are high in
mobile...