Nuclear medicine is a specialized medical field based on the application of radiopharmaceuticals, i.e. drugs associated to radioactivity, for diagnosis or therapeutic purposes. In the past fifty years, nuclear medicine has progressed in such a way that it is now a major tool in hospitals. Nowadays, this technology enables to better detect, observe and describe diseases, and also to improve treatments. Cancer therapy is the main application of this speciality. Once injected to the patient, the radiopharmaceutical drug aims selectively at the tumoral cells, including the metastases, settles...

Protein transport into the endoplasmic reticulum (ER) is just one aspect of the general cell biology topic of intracellular protein sorting. This larger picture also includes protein transport into other organelles of the eukaryotic cell (chloroplasts, mitochondria, nucleus, peroxisomes), protein export from bacteria, vesicular transport that delivers to its final destination most of what has been transported into the ER, and protein export from the ER that is associated with protein degradation (termed ERAD). Over the years, protein transport into the ER also has become part of the quest to...