The discovery of Epstein-Barr virus (EBV) by Epstein, Achong, and Barr, reported in 1964 (Lancet 1:702 703), was stimulated by Denis Burkitt s rec- nition of a novel African childhood lymphoma and his postulation that an infectious agent was involved in the tumor s etiology (Nature194:232 234, 1962). Since then, molecular and cellular biological and computational technologies have progressed by leaps and bounds. The advent of recombinant DNA technology opened the possibilities of genetic research more than most would have realized. Not only have the molecular tools permitted the analyses of...