This volume of Advances in Soft Computing and Lecture Notes in Computer th Science vols. 5551, 5552 and 5553, constitute the Proceedings of the 6 Inter- tional Symposium of Neural Networks (ISNN 2009) held in Wuhan, China during May 26 29, 2009. ISNN is a prestigious annual symposium on neural networks with past events held in Dalian (2004), Chongqing (2005), Chengdu (2006), N- jing (2007) and Beijing (2008). Over the past few years, ISNN has matured into a well-established series of international conference on neural networks and their applications to other fields. Following this tradition,...

This book not only presents the state-of-the-art research on knowledge modelling, knowledge retrieval and knowledge reuse, but also elaborates the Collaborative Knowledge Management (CKM) paradigm and the architecture for the next generation of knowledge management systems. Although knowledge management has been extensively studied, particularly in the fields of business management and engineering design, there is a lack of systematic methodologies for addressing the integrated and collaborative dimension of knowledge management during the collaborative process of designing and developing...

This book provides state-of-art statistical methodologies, practical considerations from regulators and sponsors, logistics, and real use cases for practitioners for the uptake of RWE/D. Randomized clinical trials have been the gold standard for the evaluation of efficacy and safety of medical products. However, the cost, duration, practicality, and limited generalizability have incentivized many to look for alternative ways to optimize drug development. This book provides a comprehensive list of topics together to include all aspects with the uptake of RWE/D, including, but not limited to,...