This work describes recent synthetic and analytical approaches to biological nanomaterials, specifically protein-DNA loops and nanostructures. Drs. Morgan and Kahn describe the design considerations leading to useful DNA constructs, the application of state of the art spectroscopic methods to understanding protein-DNA conformation and dynamics, and early steps toward designed protein-DNA nanostructures. Unlike most textbooks, the book also lays out some of the frustrations that impede research progress, so the reader can appreciate the human side of research on molecules.