Assigned to kill a fellow NSA operative, Agent K stumbles into a secret scheme that threatens to extinguish humankind. When a cross-dressing nun with a penchant for palindromes convinces K to stop being a yes-man and finally determine what's really going on, K sets out to solve the riddle of the dead agent's mysterious papers.

Meanwhile, strange natural disasters are killing thousands around the world, including a bloody stampede of beasts from Yellowstone National Park. As K hunts for the truth-reuniting with his estranged sister, tripping on peyote with his Irish brother-in-law,...