Epilepsy is fairly unique among the various neurological disorders as it provides the neuroscientist with almost boundless opportunities to examine basic neurobiological mechanisms. Not surprisingly, advances in epilepsy research are closely tied to dev- opment of innovative neurobiological methodologies. In many cases the practical application of these innovations especially in the context of a neurological disorder with anatomical, molecular, electrophysiological, and behavioral components such as epilepsy can be found in the development of new animal models. In turn, our understanding of...