Dopamine, involved in the etiology of CNS related disorders such as Parkinsons disease, shows poor CNS disposition following oral and IV administration due to its extensive metabolism in the GI tract and poor permeation of the blood brain barrier. However, enhanced CNS uptake of dopamine was observed following intranasal administration. Western blotting and microscopy studies revealed the expression and presence of Dopamine Transporter (DAT) and Organic Cation Transporter-2 (OCT-2) in the nasal mucosa. Bi-directional transport studies demonstrated the role of both transporters in nasal...
Dopamine, involved in the etiology of CNS related disorders such as Parkinsons disease, shows poor CNS disposition following oral and IV administratio...
People come and people go and nobody would live eternally. But if there is one person who was born 880,156 (by 2016) years ago and is still remembered even today by many people and some, howsoever miniscule they may be, worship him, is it not wise to stud
People come and people go and nobody would live eternally. But if there is one person who was born 880,156 (by 2016) years ago and is still remembered...
