The field of melanoma biology has experienced a remarkable surge in recent years, owing to progress which has ranged from the most basic laboratory/preclinical discoveries to clinical developments that have begun to transform the management and prognosis for at least certain melanoma patients. Among the key areas that have contributed to this progress are studies relating to signaling and transcriptional pathways that regulate control over differentiation and survival of the melanocyte lineage. The identification of recurring activating mutations in specific signaling factors (B-RAF, N-Ras,...

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already...

Melanoma is a cutting edge, comprehensive reference work on the topic of melanoma. The overarching goal is to provide detailed scholarly information which broadly covers all aspects of the clinical presentation and management of the disease, as well as the biological and scientific understanding of its pathogenesis and treatment. Key topics highlighted include recent breakthroughs in molecular diagnostics, breakthroughs in targeted therapeutic approaches, overviews of signaling and transcriptional pathways, and important controversies such as screening, early diagnosis, sentinel node biopsy,...