Gamma-secretase is an enzymatic complex critical to amyloid formation and other important pathophysiological processes. Non-specific gamma-secretase inhibitors are not ideal for intervention of familial Alzheimers disease. Also gamma-secretase cleaves a variety of substrates. But different sites are cleaved even in a single substrate and no consensus sequence for cleavage by gamma-secretase is identified. We hypothesize that consensus compositional sequence in components of gamma-secretase and its substrates should exist during gamma-secretase regulation and specific gammasecretase inhibitor...

Pattern matching plays a central role in different aspects of biological sequence analysis, and has been used in applications as diverse as short-gun sequencing, multiple sequence alignments, gene finding, analysis of repetition structures, searching for unique oligonucleotides, prediction of protein function and structure, sequence homology search, finding DNA-binding protein motifs, etc. Suffix trees and suffix arrays are primary data structures used in rapid pattern matching. And the problem of suffix sorting is a fundamental problem in constructing suffix arrays. This book presents the...