KLF6 is a ubiquitously expressed Kruppel-like transcription factor whose role in vitro and in vivo role has not been fully identified. Like other members of the Kruppel-like family, KLF6 contains a conserved C-terminal three zinc finger DNA-binding domain (C2H2 motifs) and a unique N-terminal transactivation domain. KLF6 directly binds DNA at GC box promoter elements. Transcriptional targets of KLF6 include collagen 1, transforming growth factor beta 1 (TGF 1), types I and II TGF receptors, urokinase type plasminogen activator (uPA), and the human immunodeficiency virus long terminal repeat...
KLF6 is a ubiquitously expressed Kruppel-like transcription factor whose role in vitro and in vivo role has not been fully identified. Like other memb...
