The therapeutic era for MS has begun, and many new, potentially effective treatments are now available. MRI offers a range of techniques which are more reliable and sensitive than any other available approach in detecting brain and spinal cord abnormalities, monitoring their evolution, and providing in vivo information about heterogenous pathological substrates of the MS lesions. Readers will find this volume a valuable summary of the state-of- the art, as well as a useful reference text from which to plan future clinical trials in MS.