Twenty-five years ago, Earl R. Stadtman, PhD discovered that specific enzymes regulating metabolism can be inactivated by oxidation 1]. He later showed that age-related oxidative modification contributes, at least in part, to age-related loss of function of the enzymes 2, 3]. Dr. Stadtman broke the ground for a new field of study to discover how oxidative stress contributes in significant ways to age-related cellular dysfunction and protein accumulation and that oxidation in the aging brain influences Alzheimer s disease, ischemia-reperfusion injury, amyotrophic lateral sclerosis, and...
Twenty-five years ago, Earl R. Stadtman, PhD discovered that specific enzymes regulating metabolism can be inactivated by oxidation 1]. He later show...
