Volume 4 of Advances in Developmental Biology and Biochemistry consists of five chapters that review specific aspects of fly and mammalian development. In Chapter 1, Y. Mishina and R. Behringer discuss various aspects of MUllerian-inhibiting substance (MIS) in mammals, from a brief history of its discovery to recent studies of the MIS gene in transgenic and knock-out animals. In Chapter 2, C. Rushlow and S. Roth discuss the role of the dpp-group genes in dorsoventral patterning of the Drosophila embryo. In Chapter 3, M. Yip and H. Lipshitz discuss the terminal (asegmental...

This series provides annual reviews of research topics in developmental biology/biochemistry, written from the perspectives of leading investigators in these fields. This volume of Advances in Developmental Biochemistry consists of seven chapters that review specific aspects of development in several different organisms including mollusks, flies and mice.

Guide to Techniques in Mouse Development, Part A comprehensively covers new technologies and methodologies that have appeared for the study of mouse development.

• Update of volume 225 of Methods in Enzymology, Guide to Techniques in Mouse Development, edited by P.M. Wassarman and M.L. DePamphilis and published in 1993
• Covers new technologies and methodologies, including:
• new techniques for the cryopreservation of gametes and embryos
• production of transgenic and null (knockout) animals (use of ES cells)
• generation of...

This volume comprehensively covers new technologies and methodologies that have appeared for the study of mouse development.

• Update of volume 225, Guide to Techniques in Mouse Development, edited by P.M. Wassarman and M.L. DePamphilis and published in 1993
• Comprehensively covers:
• new techniques for the cryopreservation of gametes and embryos
• production of transgenic and null (knockout) animals (use of ES cells)
• generation of conditional/inducible mutant animals, use of gene-trap mutagenesis
• analysis of allele-specific...

This book provides a coherent, clear, and uniform presentation of structural, genetic, molecular, and biochemical information available for the zona pellucida domain protein family, which impact pathologies such as infertility, deafness, and cancer. Furthermore it:

• Details information about the structure and function of the ZP domain in ZPDC-proteins
• Provides illustrations of the organization of ZPDC-proteins, the genes that encode the proteins, and examples of mutations in the ZP domain that cause diseases
• Speculates as to the evolution of the ZP...