This thesis investigates three aspects of alternative splicing by means of computational large-scale analyses. In the first part, we introduce a new approach for the ab initio prediction of alternative splice events. We introduce an efficient algorithm to reduce the computational complexity during the search for new splice events. Applying this algorithm to the human genome, we predict and verify novel splice events. In the second part, we investigate the influence of mRNA secondary structures on the regulation of the splicing process. We show that experimentally verified binding sites of...
This thesis investigates three aspects of alternative splicing by means of computational large-scale analyses. In the first part, we introduce a new a...