1 Introduction 1.1 Hemiballism Hemiballism or hemichorea is a rare neurological disorder, but the crucial invol- ment of the subthalamic nucleus (STN) in its pathophysiology has been app- ciated for decades (Jakob 1923; Martin 1927; Glees and Wall 1946; Whittier and Mettler 1949; Carpenter and Carpenter 1951; Crossman 1987). Only recently have serious doubts come forward. Postuma and Lang (2003) have described the STN as being involved in only a minority of cases, and indicated unrecognized causes such as non-ketotic hyperosmolar hyperglycaemia and complications of human immunodeficiency...
1 Introduction 1.1 Hemiballism Hemiballism or hemichorea is a rare neurological disorder, but the crucial invol- ment of the subthalamic nucleus (STN)...
The studies described here were carried out in the Neuroregul- ation Group, Department of Physiology, University of Leiden, the Netherlands. Over the last decade, this group, in close collaboration with the Department of Neurosurgery of the Academic Hospital of Leiden, has studied the development of the central nervous system from a neuroanatomical as well as a clinical perspective. During this period, the expression of several morphore- gulators in the developing rat spinal cord was extensively investigated. Parallel studies focused on the development of the spinal cord fiber systems, which...
The studies described here were carried out in the Neuroregul- ation Group, Department of Physiology, University of Leiden, the Netherlands. Over the ...
