The aim of this work was to develop a vaccination strategy against hepatitis C virus (HCV), which should induce the double benefit of an antibody production and a T cell immune response. The T cell response and the antibody production were examined in different mouse strains after immunization with a DNA-vaccine, which leads to expression of a protein, and compared with the T cell response after immunization with the protein. Immunization with DNA alone did not induce antibody production, but was responsible for a high production of IFN-? in all mouse strains. The immunization with protein...