The development and maintenance of muscle cells is controlled by complex regulatory networks involving epigenetic marks and trans-cription factors. While histone modifications influence the compaction of chromatin and consequently the accessibility of DNA, transcription factors are responsible for a fine tuning of expression. In this study, modern high-throughput methods of molecular biology together with bioinformatic analyses were used to decipher the architecture of these networks. The role of activating histone modi-fications and their potential interactions with key cardiac transcription...