Proteolysis is essential for life. From the breakdown of proteins in food for biosynthesis, through to antigen processing in the immune system, the blood cl- ting cascade, and the hormone-regulated remodelling of female reproductive tissues in adult mammals - proteolysis governs functionality, homeostasis, and fate at the levels of the cell and the entire organism. For the cancer cell, intracellular prote- ysis carried out by caspases and the proteasome must be enlisted and controlled to allow it to escape apoptosis. Functioning on the cancer cell surface or in the extracellular milieu,...

This book covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; and many other relevant subjects, including new approaches to targeting proteolysis for therapy.

Being legally dead is causing Razi some problems, and xer only chance of escape from bureaucratic limbo will involve a dangerous trek through wolfcat territory. Meanwhile, Halvanylila is supposed to be learning to hunt and fight, but it's hard to concentrate when there are fascinating plants to be scienced at. Now they're both lost in the middle of nowhere, and they'll need each other's help and unique expertise to find their way out. One problem: those wolfcats. Oh, wait, and a troupe of bandits? Two problems. But hey, as long as nothing else goes wrong ...