In this comprehensive guide, Chow and his co-authors (all experimental surgery, Singapore General Hospital) explain the characteristics and handling of animals used in biomedical research, practical details on managing a modern research animal facility (including imaging equipment), and the variety of uses of animal models. Topics include scientific considerations and choice of species, including the use of non-human primates, regulatory considerations in the use of animal models (with concentration on those of Singapore), animal handling and surgical procedures, including blood collection,...