This latest edition to the 'Contemporary Neurology Series' will fill one of the few remaining 'neurologic gaps' within the Series. 'Multiple Sclerosis, ' written solely by Moses Rodriguez, Orhun Kantarci and Istvan Pirko of the Mayo Clinic in Rochester, MN will offer proven, effective treatments for specific presentations and symptoms of multiple sclerosis along with a pathophysiological explanation of why they work. It bridges a needed gap between overly simplistic therapy manuals and basic science texts that discuss human disease only insofar as it mimics what is observed in animal models...

Immunoglobulins with germline sequences occur in invertebrates and vertebrates and are named 'natural antibodies' (NAbs). They may target foreign antigens, self- or altered self-components and are part of the normal immunoglobulin repertoire. NAbs can act as systemic surveillance molecules, which tag damaged or stressed cells, invading pathogens and toxic protein aggregates for elimination by the immune system. Certain NAbs actively signal in different cell types with a broad range of responses from induction of apoptosis in cancer cells, stimulation of remyelination in glial cells and...