Group I metabotropic glutamate receptors (mGluRs) play an important role in the treatment of numerous neurodegenerative, cognitive and psychiatric dis­orders. How can we identify exogenous ligands mediating the effects of mGluRs? How do these ligands affect the receptor?
The author Tobias Noeske presents the establishment of strategies for the identification and optimization of molecules acting as non-competitive anta­gonists of group I mGluRs. These strategies ensure high diversity in the identi­fied chemotypes not resembling original reference molecules ("scaffold-hop­ping"). The...