These proceedings survey the latest developments in a wide area of mathematical physics as presented by internationally renowned experts. The fields surveyed are High Energy Physics, String Theory, Relativity, Astrophysics, Cosmology, Plasma Physics and Formal Aspects of Mathematical Physics. Some of the exciting topics discussed in this volume are fundamental questions about black holes and string theory, supermassive black holes, string theory and the quantum structure of space-time, AdS space-time and holography, the cosmological constant, non-commutative geometry, quantum gravity,...