Vectors based on adenoviruses have been designed as targeted anti-cancer therapeutics that showed promising results in pre-clinical applications. Particularly, efforts have focused on the development of oncolytic vectors that can eliminate cancer cells and replicate in a tumor-selective fashion to amplify the input dose. In clinical trials, these oncolytic adenoviruses have generally been proved safe in patients, but have fallen short of their expected therapeutic value as monotherapies. A number of obstacles that hamper the efficacy of adenoviral vectors have been identified. These include...

Foreword Reviews' INDIEFAB Book of the Year Winner in Biography "The Funniest. Presidential. Biographer. Ever." --Kai Bird, Pulitzer-prize winning historian Now in paperback, W.P.E. flips the great presidential biography on its head, offering an enlightening--and highly entertaining --account of poor James Buchanan's presidency. This book proves once and for all that, well, few leaders could have done worse. But author Robert Strauss also explores with insight and humor the entire notion of ranking our presidents. He guides us through the POTUS rating game played by historians and others, the...

The purpose of Introducing Story-Strategic Methods is to awaken us in the cross-cultural context. Our natural tendency is to be asleep to our own cultural values and core worldview assumptions. This tendency applies as well to our expectations in the cross-cultural context. For example, in what ways would a ""justice"" pattern of culture orient our speech and behavior? To what degree is a ""justice"" pattern of culture different from an ""honor"" pattern of culture? The book asserts that culture matters in effective communication. Going further, to what degree does a story told from the Bible...