This book constitutes the thoroughly refereed post-proceedings of the 7th International Conference on High Performance Computing for Computational Science, VECPAR 2006, held in Rio de Janeiro, Brazil, in June 2006. The 44 revised full papers presented together with one invited paper and 12 revised workshop papers cover Grid computing, cluster computing, numerical methods, large-scale simulations in Physics, and computing in Biosciences.

The LNCS journal Transactions on Large-Scale Data and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing (e.g., computing resources, services, metadata, data sources) across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems...