Maybelle the cockroach loves tasty crumbs and scrumptious sprinkles, but she is tired of braving the dangers of Mr. and Mrs. Peabody's kitchen: the flattening feet, the bright light, and especially the cat, Ramona.

Enter Bernice. She's an ant with a head cold who can't find her way back to her nest, and she adopts Maybelle as her new queen. But Bernice has a habit of getting into trouble, causing the Peabodys to think their house is haunted. Can't a cockroach ever get a break?