This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights.The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable...

Dieses Buch fuhrt in die wichtigsten Theorien des Alterns ein; es konzentriert sich auf Telomere, DNA-Schadigung, oxidativen Stress, die Rolle der Nahrstoffversorgung bzw. -erkennung, das Zusammenspiel von Genen und Umwelt (Epigenetik) und die Proteinhomoostase und stellt einige Gene vor, die die Lebensdauer in Modellorganismen zu verandern in der Lage sind. Indem es die verschiedenen das Altern bestimmenden Faktoren mit Erkrankungen des Menschen verknupft, sucht das Buch ihre vielfaltigen Wechselbeziehungen und Abhangigkeiten aufzuzeigen und zu einer molekularen Matrix des Alterns...

This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights.The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable...

A Structure-Function Toolbox for Membrane Transporter and Channels, Volume 594, a new release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New chapters in the updated serial include Cryo-EM on membrane proteins embedded in nanodics, Solid-Supported membrane-based electrophysiology on membrane transporters and channels, Saposin-lipoprotein scaffolds for structure determination of membrane transporters and channels, Single-molecule FRET on transporters, Dynamics of channels and...