Designed to be a practical handbook on clinical trial management in these key therapeutic areas, 'Clinical Trials in Rheumatoid Arthritis and Osteoarthritis' is aimed at principal investigators pharmaceutical physicians and other pharmaceutical staff involved in the design, conduct and monitoring of these increasingly complex diseases.

In the last several years a new classes of biologic agents have emerged and changed the treatment paradigm for patients, not only with classically defined rheumatoid arthritis, but also with other related diseases such as ankylosing...

R. P. PHARIS and D. M. REID The idea of a separate Encydopedia volume dealing with the "interrelations of plant hormones with factors in the environment of the plant, and its organs and tissues" originated with N. P. KEFFORD, and we are most appreciative of the help and advice provided by Prof. KEFFORD in the formative stages of this volume. We have thus interpreted "environment" very broadly to indude not only factors external to the plant, e. g., gravity, light, temperature, wind, mechanieal wounding, water, organism s (induding pollen), and magnetic and electric stimuli, but internaI...