Serpins constitute a superfamily of proteins that possess a unique tertiary structure and mechanism of proteinase inhibition. In humans, serpins constitute 10% of the plasma proteins and are best known as critical regulators of both the thrombotic and fibrinolytic systems. Serpins also participate in the regulation of the complement cascade, angiogensis, tumor metastasis, apoptosis and innate immunity. Considering the importance of these molecules in regulating proteolytic cascades, it is not surprising to find that this loss-and gain-of function mutations result in significant human...

Neonatology is an expanding subspecialty with recent advances in treatment modalities and increased survival rates. With a better understanding of the pathogenesis of neonatal conditions, therapeutic and medical decisions are becoming more complex and require a multi-disciplinary approach. There are several handbooks of neonatology currently available but none of them offer a comprehensive guide to neonatal care. This handbook offers a unique, multi-disciplinary approach to most of the disease states encountered in the neonatal intensive care unit. It includes a special focus on prenatal...