The design of an adequate surgical model, like the choice of the animal model itself, is extremely important for obtaining reliable valuable data. Written for biomedical researcher this manual on the surgery of the rat summarizes a series of techniques that have been applied at the Bone Biology Laboratories, School of Medicine, Rosario National University, Argentina. Stopping short of an exhaustive analysis of the techniques, the manual describes the basis of each surgical technique, the necessary materials including catheters, precautions to consider, the methodology to apply and the...