Anti-Angiogenic Cancer Therapy provides information on the process of angiogenesis and its role in tumor growth and metastasis. This book examines angiogenesis inhibitors under clinical investigation as well as early agents used in preclinical studies. It discusses the unique aspects of targeting and inhibiting angiogenesis and the challenges associated with clinical development of angiogenesis including trial design and surrogate marker endpoints. With information on the design and execution of preclinical studies, the application of genomics and angiogenesis, and the regulatory approval...