The HIV/AIDS pandemic is the most devastating global public health crisis since the great plagues of the Middle Ages, with more than 14,000 new HIV infections and 8,000 deaths due to AIDS every day. Although successful vaccines have been developed for most common childhood diseases, the development of a vaccine against the AIDS virus is a much greater challenge. More than 20 years after the discovery of the virus, the goal of a licensed and globally accessible vaccine is still several years away. AIDS Vaccine Development reviews the scientific challenges that have impeded the search for an...