Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.

Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:

• key interplay between transporters and enzymes in drug metabolism and drug interactions
• the integral role of pharmacogenetics in metabolism-based drug-drug interactions
• in vivo - in vitro correlations (reversible,...