Mixed-e?ects models provide a ?exibleand powerful toolfor theanalysis of grouped data, which arise in many areas as diverse as agriculture, biology, economics, manufacturing, and geophysics. Examples of grouped data - clude longitudinal data, repeatedmeasures, blocked designs, and multilevel data. The increasing popularity of mixed-e?ects models is explained by the ?exibility they o?er in modeling the within-group correlation often present in grouped data, by the handling of balanced and unbalanced data in a uni?ed framework, and by the availability of reliable and e?cient software for ?tting...
Mixed-e?ects models provide a ?exibleand powerful toolfor theanalysis of grouped data, which arise in many areas as diverse as agriculture, biology, e...
This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the full spectrum of topics involved in the adaptive designs arena, it will serve as a valuable reference for researchers working in industry, government and academia. The target audience is anyone involved in the planning and execution of clinical trials, in particular, statisticians, clinicians, pharmacometricians, clinical operation specialists, drug supply managers, and infrastructure providers. In spite of the increased efficiency of adaptive...
This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the ...
This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the full spectrum of topics involved in the adaptive designs arena, it will serve as a valuable reference for researchers working in industry, government and academia. The target audience is anyone involved in the planning and execution of clinical trials, in particular, statisticians, clinicians, pharmacometricians, clinical operation specialists, drug supply managers, and infrastructure providers. In spite of the increased efficiency of adaptive...
This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the ...
